Nucleophilic vinylic “addition-eliminati
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Vincent C.O. Njar; Gregory T. Klus; Angela M.H. Brodie
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Article
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1996
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Elsevier Science
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English
⚖ 283 KB
We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4