The reaction between ketones and t-butylallyl magnesium bromide. A sensitive measure of steric hindrance in the neighbourhood of the carbonyl group.

The influence of steric and torsional st

The influence of steric and torsional strain on the steric course of additions to cyclohexanones. The reaction between 4-T-butylcyclohexanone and T-butylallyl magnesium bromide.

✍ Marc Chérest; Hugh Felkin 📂 Article 📅 1971 🏛 Elsevier Science 🌐 French ⚖ 204 KB

The steric outcome of the reactions of simple cyclohexanones (e.g., 1) vith hydrides and Grignard reagents is governed by the relative magnitudes of the strains in the transition states At and E', leading to the axial ,2& and equatorial ZE alcohols respectively.le2 t BB" 'a 1 . 24