An efficient approach for the rapid asse
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Hyo-Kyung Han; Nalini Sadagopan; Gregory A. Reichard; Udeni Yapa; Tong Zhu; Andr
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Article
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2006
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John Wiley and Sons
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English
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Present study aims to improve efficiency and capacity of in vivo rat pharmacokinetic studies for rapid assessment of systemic exposure (AUC and C(max)) of new chemical entities. Plasma concentration-time profiles in rats from structurally diverse compounds were extracted from the Pfizer database. AU