The rational design and application of new chiral phosphonates for the enantiomeric excess determination of unprotected amino acids. Remarkable pH dependency of the diastereomeric shift differences.

✍ Scribed by Ron Hulst; N.Koen de Vries; Ben L. Feringa

• Book ID: 104203442
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 567 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)85665-9

✦ Synopsis

Abetmek .-CT amide derivativea of &kid phosph~ 8 and qmt&ed alninoecids are easily prepmd in aqueous solutions, showing well sepmted sigmds in the "P NMR spectra allowing acauate enmtiome.ric excess detamimtion. Moreover, the obtained di -eric sm diqmsion appears to be highly pH dependent, indiceting the influena. of intramolecular ion pair formation on the dimtememeric shift dispersion.