The Linear Dependence of Log(kcat/Km) fo
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Jia Luo; Kalju Kahn; Thomas C. Bruice
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Article
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1999
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Elsevier Science
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English
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Like most dehydrogenases, with horse liver alcohol dehydrogenase (LADH), a bulky amino acid residue (Val 203) is positioned at the face of NAD + distal to substrate alcohol in order to restrict the separation of reactants and to control the stereochemistry. Molecular dynamics simulations of native (