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The ras antagonist s-farnesylthiosalicyclic acid induces inhibition of mapk activation

✍ Scribed by M. Gana-Weisz; A. Paz; R. Haklai; D. Marciano; Y. Kloog

Book ID: 117476274
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 19 KB
Volume: 237
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(97)90070-7

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## Abstract Human lung neoplasms frequently express mutations that down‐regulate expression of various tumor suppressor molecules, including mitogen‐activated protein kinases such as p38 MAPK. Conversely, activation of p38 MAPK in tumor cells results in cancer cell cycle inhibition or apoptosis ini