โ Scribed by Stephen G Pauker; Boaz Avitall; Herbert J Levine; Shapur Naimi
No coin nor oath required. For personal study only.
A system was developed to allow for the rapid evaluation of myocardial excitability and conduction in canine preparations. The stimulus strength required to excite a propagated response, as a function of time since the last depolarization, can be summarized by a strength-interval curve. Our system generates strength-interval curves under computer control with high accuracy and efficiency. The conduction time of each ventricular response is also determined. At a heart rate of 2.5 Hz, the average time for curve generation is 94 s, an efficiency which is 85% of the theoretical maximum. This system has been employed in over 120 dogs to generate strength-interval curves during rapidly changing periods of myocardial ischemia and during interventions with various drugs.
Electrophysiology Myocardial conduction Myocardial excitability Myocardial ischemia
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