The random introduction of patients into a clinical trial: Various aspects of estimates and probabilities of survival

✍ Scribed by G.M. Tallis; G. Sarfaty; P. Leppard

• Book ID: 103051788
• Publisher: Elsevier Science
• Year: 1977
• Tongue: English
• Weight: 455 KB
• Volume: 10
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(77)90037-4

✦ Synopsis

A feature of some medical studies is that patients enter the trial at different times. At the close of the trial they have been observed for varying periods and any analysis of survival must consider this feature of random entry. We propose a simple model to cope with the above situation. One advantage of this approach is that it allows for the model assumptions to be tested statistically. The model is illustrated with the survival data from a breast cancer investigation conducted in Victoria, Australia. Personalized, conditional probabilities and expectations of survival following adrenalectomy are discussed and the latter functions have been programmed for use in a clinical context. Survival is studied further and is related to the response to the treatment by adrenalectomy for women with advanced disease. This work bears on previous results reported in this journal.