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The quinolone, flumequine, has no effect on theophylline pharmacokinetics

✍ Scribed by B. Lacarelle; O. Blin; C. Audebert; P. Auquier; H. Karsenty; F. Horriere; A. Durand

Publisher
Springer
Year
1994
Tongue
English
Weight
191 KB
Volume
46
Category
Article
ISSN
0031-6970

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✦ Synopsis

The kinetics of a single i.v. dose of theophylline given either alone or with flumequine was studied in eight healthy volunteers. No statistically significant differences were observed in the pharmacokinetic parameters of theophylline (volume of distribution, elimination half-life, AUC, plasma clearance) following the two treatments. Pretreatment for 5 days with oral flumequine (400 mg, three times daily) had no significant effect on the disposition of a single i.v. dose of theophylline in healthy volunteers.

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