The quantitative investigation of the binding process of calcium blocking drugs in a sinoatrial node

✍ Scribed by R. Plonsey; C.F. Starmer; I. Tipāns

• Book ID: 104154716
• Publisher: Elsevier Science
• Year: 1991
• Tongue: English
• Weight: 297 KB
• Volume: 149
• Category: Article
• ISSN: 0022-5193
• DOI: 10.1016/s0022-5193(05)80071-2

✦ Synopsis

Application of existing models of sinoatrial node pacemaker activity and of channeldrug interaction allow us to reproduce action potential changes as a result of the blocking effect of drugs. Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated. The procedure applied which is based on experimental results and on computer simulations, can be used as an initial step for comparison of different drugs.