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The purification and characterization of deoxycytidine kinase from calf thymus

✍ Scribed by Jing Quan; Yan-Qian Chai; Christopher J. Branford-White; Li-Min Zhu


Publisher
Springer
Year
2008
Tongue
English
Weight
400 KB
Volume
25
Category
Article
ISSN
1573-0972

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Damage to DNA can result in strand breaks with 58-hydroxyl and 38-phosphate termini. Before DNA polymerases and ligases can rejoin the broken strands, such termini have to be restored to 58-phosphate and 38-hydroxyl groups. Polydeoxynucleotide kinase is an enzyme that may fulfil this function. We ha