𝔖 Bobbio Scriptorium
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The pulsed dye laser and atherosclerotic vascular disease

✍ Scribed by Mr A. Murray; P. R. Crocker; R. F. M. Wood

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
426 KB
Volume
75
Category
Article
ISSN
0007-1323

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✦ Synopsis

The pulsed dye laser and atherosclerotic vascular disease

The use of a pulsed dye laser to ablate atheromatous tissue obtained from post-mortem human aortic specimens is reported. Laser energy was delivered with a 600 pm quartz j b r e , at a wavelength of 504 nm and a pulse length of 1 ps. Pulse energy was varied fiom 30-140 mJ, producing peak pulse powers of the order of 100 kW. With these parameters the laser ablated fatty, jbrous and calcified plaques. At this wavelength atheroma is vaporized but there is minimal damage to normal vessel wall, due to preferential absorption of the laser light. Light microscopy shows that by microsecond pulsing, thermal damage to surrounding tissues associated with continuous wave lasers is avoided. Transmission electron micrographs reveal a sharp demarcation between a laser crater and the adjacent vessel wall with little ultrastructural disruption. Scanning electron micrographs show the crater walls to be smooth. The pulsed dye laser may therefore be effective in the treatment of occlusive peripheral vascular disease without undue risk of vessel perforation.

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