The psychopharmacology of clobazam

✍ Scribed by Ian Hindmarch

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 1010 KB
• Volume: 10
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470100703

✦ Synopsis

GU7 I UF, EngIand

The psychopharmacology of clobazam, specifically its effects on CNS arousal, cognitive and memory functions and psychomotor performance, is reviewed. Compared with the I ,It-benzodiazepine tranquillizers, clobazam is characterized by a lack of sedative and amnestic effects and no impairment of psychomotor skills including car driving, both in volunteer and clinically anxious patient populations. Clobazam also compares favourably with buspirone, a nonbenzodiazepine anxiolytic agent. Differentiation of the psychopharmacological profile of clobazam from the 1,4benzodiazepines suggests important phannacodynamic differences between the two groups. These in turn represent significant advantages for the clinical use of clobazam in the management of ambulant patients with anxiety.