✦ LIBER ✦

The psychopharmacological effects of single doses of prolonged release formulations of dimethindene and chlorpheniramine in human volunteers

✍ Scribed by Anthony Lee; Malcolm Lader; Mary Ellen Kitler

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 423 KB
Volume: 3
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470030207

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of single doses of dimethindene (retard) 2.5 mg, chlorpheniramine (TD) 12mg and placebo on a battery of physiological, performance and subjective measures were studied in a double-blind, crossover study in 12 healthy subjects. Dimethindene had a different EEG profile from chlorpheniramine; while both active drug treatments were associated with an increase in 8.0-13.0 Hz waveband activity, dimethindene alone produced less 2.0-4.0 Hz activity. The two active drugs were associated with an improvement in tapping rate. Dimethindene had no effect on simple reaction time, while chlorpheniramine was associated with a slowing in this measure. Subjective measures generally indicated an improvement in general alertness and contentedness with both dimethindene and chlorpheniramine. It is concluded that single doses of sustained-release formulations of these antihistamines are slightly stimulant in effect and are useful where sedation is unacceptable.

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