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The proximal GC-rich region of p16INK4agene promoter plays a role in its transcriptional regulation

โœ Scribed by Xiuli Wang; Yunpeng Feng; Lina Pan; Yanle Wang; Xin Xu; Jun Lu; Baiqu Huang


Book ID
106458202
Publisher
Springer
Year
2007
Tongue
English
Weight
328 KB
Volume
301
Category
Article
ISSN
0300-8177

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## Silencing of p16 INK4a by methylation of the CpG islands in the promoter region has been found to be an alternative mechanism of inactivation in several tumors. However, in gastric carcinoma, the relationship between methylation status and the transcriptional silencing of the p16 gene remains t