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The proto-oncogene AKT is overexpressed in human and experimental colorectal carcinogenesis

✍ Scribed by Bola F. Olusola; Thomas C. Smyrk; Anne Ratashak; Hemant K. Roy


Book ID
119425392
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
194 KB
Volume
118
Category
Article
ISSN
0016-5085

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AKT2, an oncogene encoding a protein serine-threonine kinase implicated in phosphatidylinositol-3-OH kinase signaling, is amplified in some human ovarian and pancreatic carcinomas. We previously demonstrated that the tumorigenicity and invasiveness of pancreatic ductal adenocarcinoma (PDAC) cell lin