Amplification and overexpression of the
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Bruce A. Ruggeri; Lingyi Huang; Moira Wood; Jin Quan Cheng; Joseph R. Testa
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Article
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1998
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John Wiley and Sons
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English
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AKT2, an oncogene encoding a protein serine-threonine kinase implicated in phosphatidylinositol-3-OH kinase signaling, is amplified in some human ovarian and pancreatic carcinomas. We previously demonstrated that the tumorigenicity and invasiveness of pancreatic ductal adenocarcinoma (PDAC) cell lin