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The protein kinase C delta inhibitor rottlerin greatly stimulates apoptosis in pancreatic cancer cells

✍ Scribed by Moussa Yazbeck; Kyung J. Nam; Eva C. Vaquero; Anna S. Gukovskaya; Stephen J. Pandol

Book ID: 119427366
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 173 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(03)80508-5

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## Abstract The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3–100 µM) increased the amplitude of Ca^2+^‐activated K^+^ current (I~K(Ca)~) in a concentration‐dependent manner with an EC~50~