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The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

โœ Scribed by Adam C Bell; Adam G West; Gary Felsenfeld


Book ID
117268624
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
448 KB
Volume
98
Category
Article
ISSN
0092-8674

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Activation of gene transcription in metazoans is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. One class of co-activator, the TAF(II