The protective properties of synthetic porphyrin tin complexes in toxic hyperbilirubinemia

✍ Scribed by T. O. Philippova; B. N. Galkin; N. Ya. Golovenko; Z. I. Zhilina; S. V. Vodzinskii

• Book ID: 101290502
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 112 KB
• Volume: 04
• Category: Article
• ISSN: 1088-4246
• DOI: 10.1002/(sici)1099-1409(200004/05)4:3<243::aid-jpp201>3.0.co;2-d

✦ Synopsis

Tin complexes of meso-substituted synthetic porphyrins, namely Sn^4+^-meso-tetraphenyl- porphyrin ( Sn - TPP ) and Sn^4+^-meso-tetrakis(N-methyl-3-pyridyl)porphyrin tetratosylate ( Sn - TMe -3- PyP ), efficiently decrease the serum bilirubin level when injected subcutaneously at a dose of 100 μM kg^−1^body weight into mice. These compounds are active during hyperbilirubinemia, induced by phenylhydrazine, hemin and tetrachloromethane, and also during autoimmune hemolytic anemia. In the latter case a decrease in serum bilirubin content was observed, as well as a decrease in the amount of blood reticulocytes which reflects a milder course of the disease. The Sn complexes under study induce, in vivo, cytochrome P-450, inhibit microsomal heme oxygenase and decrease the intensity of lipid peroxidation. At the same time, in vitro the hepatic and splenic heme oxygenase activity is blocked only when a 0.1 μM concentration of Sn - TMe -3- PyP or Sn -protoporphyrin IX is added to the incubation mixture. Sn - TPP does not affect the activity of this enzyme in vitro.