✦ LIBER ✦

The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67

✍ Scribed by Yulian Wu; Hongyu Luo; Nada Kanaan; Jiangping Wu

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 199 KB
Volume: 76
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(20000315)76:4<596::aid-jcb8>3.0.co;2-n

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✦ Synopsis

The proteasome is a protease complex responsible for rapid, selective, and irreversible removal of regulatory proteins, as well as many other cellular proteins. In this study, we have demonstrated that a proliferationassociated nuclear protein Ki-67 depended on the proteasome for its rapid degradation. A proteasome-specific inhibitor lactacystin augmented Ki-67 protein levels in pancreatic cancer BxPC-3 cells while repressed the level of steady-state Ki-67 mRNA. Inhibition of the proteasome also led to accumulation of two CDK inhibitors p27 kip1 and p21 cip1 in the BxPC-3 cells. Failed reduction of Ki-67 protein and enhanced levels of the two CDK inhibitors are likely contributing factors for the suppressed BxPC-3 proliferation after proteasome inhibition.

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