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The Proteasome: A Target of Oxidative Damage in Cultured Human Retina Pigment Epithelial Cells

✍ Scribed by Zhang, Xinyu ;Zhou, Jilin ;Fernandes, Alexandre F. ;Sparrow, Janet R. ;Pereira, Paulo ;Taylor, Allen ;Shang, Fu

Book ID
118175532
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Year
2008
Weight
337 KB
Volume
49
Category
Article
ISSN
1552-5783

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## Abstract The largest isoform of the Shc adapter protein, p66Shc, has been implicated in oxidative damage‐induced apoptosis in vital organs, because mice deficient in p66Shc have a 30% increase in life span and are resistant to the lethal effects of systemically administered paraquat, a source of