✦ LIBER ✦

The promiscuous mGlu5 receptor – a range of partners for therapeutic possibilities?

✍ Scribed by Michael K. Bird; Andrew J. Lawrence

Book ID: 116918915
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 237 KB
Volume: 30
Category: Article
ISSN: 0165-6147
DOI: 10.1016/j.tips.2009.09.008

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Is the mGlu5 receptor a possible target

Is the mGlu5 receptor a possible target for new antidepressant drugs?

✍ Pałucha-Poniewiera, Agnieszka; Wierońska, Joanna M.; Brański, Piotr; Burnat, Grz 📂 Article 📅 2013 🏛 Elsevier 🌐 English ⚖ 442 KB

Synthesis of [3H]fenobam, a radioligand

Synthesis of [3H]fenobam, a radioligand for the mGlu5 receptor

✍ Thomas Hartung; Jens-Uwe Peters; Jürgen Wichmann; Christian Hubschwerlen; Georg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB

## Abstract Fenobam is a clinically efficacious anxiolytic that acts as metabotropic glutamate receptor 5 (mGlu5) antagonist by binding to an allosteric site. Other mGlu5 receptor antagonists such as MPEP and MTEP bind to the same allosteric site and are efficacious in preclinical models of anxiety

A critical pocket close to the glutamate

A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

✍ Francine C. Acher; Chelliah Selvam; Jean-Philippe Pin; Cyril Goudet; Hugues-Oliv 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 890 KB

Neuroprotective activity of the potent a

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors

✍ V Bruno; G Battaglia; A Kingston; M.J O’Neill; M.V Catania; R Di Grezia; F Nicol 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 426 KB

ImMucin: A novel therapeutic vaccine wit

ImMucin: A novel therapeutic vaccine with promiscuous MHC binding for the treatment of MUC1-expressing tumors

✍ Riva Kovjazin; Ilan Volovitz; Yulia Kundel; Eli Rosenbaum; Gal Medalia; Galit Ho 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 687 KB

A novel selective metabotropic glutamate

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

✍ Goudet, C.; Vilar, B.; Courtiol, T.; Deltheil, T.; Bessiron, T.; Brabet, I.; Oue 📂 Article 📅 2012 🏛 The Federation of American Societies for Experimen 🌐 English ⚖ 875 KB