The proliferation of prostatic epithelium in chronic prostatitis
✍ Scribed by Stiens, R. ;Helpap, B. ;Br�hl, P.
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 313 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0300-5623
No coin nor oath required. For personal study only.
✦ Synopsis
The labelling index in chronic nonspecific prostatitis ranges from 0.7-2.1%. This value is markedly higher than in nodular hyperplasia (0.4%) as well as in differentiated adenocarcinomas (0.6%). Increased labelling index could only be determined in glands adjacent to inflammatory foci. In recognition of these findings we believe that a correct evaluation of the cell proliferation in chronic prostatitis is only possible if each single cell can be evaluated, whether it is altered by inflammation or not. Therefore, solid tissue biopsies appear to be more suitable in autroadiographical studies than cytological material alone.
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The androgen receptor pathway is known to be a key regulator of growth in the normal and pathological prostate. However, the precise mechanisms of this signaling pathway with respect to the different cellular compartments of the prostate remain largely unknown. We have used a primary culture system