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The Proinflammatory Cytokines Interleukin-l and Tumor Necrosis Factor and Treatment of the Septic Shock Syndrome

✍ Scribed by Dinarello, C. A.

Book ID
124078275
Publisher
University of Chicago Press
Year
1991
Tongue
English
Weight
894 KB
Volume
163
Category
Article
ISSN
0022-1899

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Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim o