The production of congenital malformations using tissue antisera. IV. Evaluation of the mechanism of teratogenesis by varying the route and time of administration of anti-rat-kidney antiserum
✍ Scribed by Brent, Robert L.
- Book ID
- 102697392
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1966
- Tongue
- English
- Weight
- 643 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0002-9106
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✦ Synopsis
Sheep anti-rat-kidney serum and rabbit anti-rat-kidney serum were utilized in a number of biological studies in order to clarify some of the qualitative and quantitative effects of this antiserum. The teratogenic factor or factors present in these antisera can be characterized as follows: The antiserum is (1) ineffective when administered by the oral route; ( 2 ) the antiserum is teratogenic when administered by the intravenous, intraperitoneal, subcutaneous or intrauterine route; (3) more effective by the intravenous and intraperitoneal route than by the subcutaneous route and (4) no more effective when injected into the uterine lumen of a pregnant rat than when given intravenously; ( 5 ) uterine vascular clamping experiments and injection of the antiserum during the preimplantation period indicate that the teratogenic milieu persists for days following the administration of the antiserum; (6) the antiserum can be considered a classical teratogenic agent because it produces a different spectrum of malformations on different days of gestation and concomitant fetal mortality and growth retardation; although stage specificity is not as dramatic with