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The pro-region of the yeast prepro-α-factor is essential for membrane translocation of human insulin-like growth factor 1 in vivo

✍ Scribed by Bhabatosh CHAUDHURI; Klaus STEUBE; Christine STEPHAN


Book ID
115129363
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
944 KB
Volume
206
Category
Article
ISSN
1432-1327

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## Abstract Type 1 insulin‐like growth factor receptor (IGF1R) signaling in neuronal development was studied in mutant mice with blunted __igf1r__ gene expression in nestin‐expressing neuronal precursors. At birth [postnatal (P) day 0] brain weights were reduced to 37% and 56% of controls in mice h