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The principal neutralizing determinant of HIV-1IIIB: Conformation of the peptide bound to a neutralizing antibody studied by 2D-NMR

โœ Scribed by Anat Zvi; Jacob Anglister


Book ID
105576438
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
721 KB
Volume
5
Category
Article
ISSN
1573-3149

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Fab-peptide complexes formed between a 15 residue peptide derived from the HIV-1 gp120 V3 loop and two of its cognate monoclonal antibodies, 5023A and 5025A, were studied using isotope-edited solution nuclear magnetic resonance (NMR) techniques. Since these antibodies neutralize HIV-1 virus with dif