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The primary structure of noxiustoxin: A K+channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann

✍ Scribed by Lourival Domingos Possani; Brian M. Martin; IB Svendsen

Publisher: Springer-Verlag
Year: 1982
Weight: 351 KB
Volume: 47
Category: Article
ISSN: 0105-1938
DOI: 10.1007/bf02907789

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The solution structure of a synthetic peptide, Cn2(1-15)NH 2 -S-S-acetyl-Cn2(52-66)NH 2 from toxin 2 (Cn2) of the New World scorpion Centruroides noxius was determined using nmr and molecular dynamics calculations. The peptide has no significant secondary structure such as an ␣-helix or a ␤-sheet, y