The prevalence and clinical significance of α1-antitrypsin deficiency (PiZ) and anca specificities (proteinase 3, BPI) in patients with ulcerative colitis
✍ Scribed by Abdul-Nasser Elzouki; Sten Eriksson; Robert Löfberg; Lennart Nässberger; JÖRgen Wieslander; Dr. Stefan Lindgren
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 626 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1078-0998
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✦ Synopsis
Our aim was to determine the prevalence of the PiZ allele for qantitrypsin (AAT) deficiency and some relevant antineutrophil cytoplasmic antibody (ANCA) specificities in patients with ulcerative colitis (UC), and explore a possible association between these markers. In addition, we studied the relation to disease extension and activity. Sera from 141 patients with UC (72 women) were analyzed while SO blood donors and 54 patients with acute myocardial infarction served as controls. Serum samples were screened for PiZ with ELISA and phenotyped by isoelectric focusing. BPI-ANCA and PR3-ANCA were detected by ELISA. Results were that 8.5% (12/ 141) of the patients with UC were PiZ carriers, higher than expected in the general Swedish population (4.7%) (p = 0.03). There was a significant difference between PiZ-camers and non-PiZ-caniers in the extension and severity of colitis (odds