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The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

✍ Scribed by Paul H. Wen; Patrick R. Hof; Xiaoping Chen; Karen Gluck; Gregory Austin; Steven G. Younkin; Linda H. Younkin; Rita DeGasperi; Miguel A. Gama Sosa; Nikolaos K. Robakis; Vahram Haroutunian; Gregory A. Elder

Book ID
116458261
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
763 KB
Volume
188
Category
Article
ISSN
0014-4886

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## Abstract Formation of new neurons in the adult brain takes place in the subventricular zone and in the subgranule layer of the dentate gyrus throughout life. Neurogenesis is thought to play a role in hippocampus‐ and olfaction‐dependent learning and memory. However, whether impairments in neurog