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The presence of γ-carboxyglutamic acid in the proteins associated with ectopic calcification

✍ Scribed by Jane B. Lian; Martha Skinner; Melvin J. Glimcher; Paul Gallop

Book ID
118310807
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
522 KB
Volume
73
Category
Article
ISSN
0006-291X

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✍ James R. Cairns; Matthew K. Williamson; Paul A. Price 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 430 KB

We report the first direct method for the identification of the vitamin K-dependent Ca2+ binding amino acid, gamma-carboxyglutamic acid (Gla), in the sequencing of proteins. The carboxyl groups on the protein are first converted to methyl esters with methanolic HCl, a procedure that reduces the pola