The presence of persistent high-risk hpv genotypes in dysplastic cervical lesions is associated with progressive disease: Natural history up to 36 months
✍ Scribed by Ans J. Remmink; Jan M. M. Walboomers; Theo J. M. Helmerhorst; Feja J. Voorhorst; Lawrence Rozendaal; Ellen K. J. Risse; Chris J. L. M. Meijer; Peter Kenemans
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 704 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
To evaluate the clinical significance of HPV genotyping for the prediction of progressive cervical intraepithelial neoplasia (CIN) in women with cytomorphologically abnormal smears, a prospective, blind, non-intervention study was performed. A total of 342 patients screened with cytomorphologically abnormal cervical smears were monitored every 3-4 months by cervical cytology, colposcopy and HPV testing using PCR. Women with progressive CIN disease were defined as patients developing lesions with a colposcopic impression of CIN 111 over more than 2 quadrants or resulting in a cytological smear equivalent to Pap 5. These patients were subsequently treated according to standard procedures. If any doubt arose about the true status of the patients (n = 75) these patients were censored and biopsied. The mean follow-up time was 16.5 months (range 3-36 months). Nineteen women showed progressive CIN disease and all appeared to be continuously HPV-positive from the start of the study. A t biopsy, all these patients were histologically classified as CIN 111. Seventeen of these women were positive for high-risk HPV types. Two cases were classified as still