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The presence of cachectin/tumor necrosis factor in human disease states

✍ Scribed by Bruce Beutler

Book ID
115682431
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
234 KB
Volume
85
Category
Article
ISSN
1555-7162

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Tumor necrosis factor/cachectin (TNF) is a potent pleiotropic cytokine implicated in a number of pathological conditions including septic shock and cachexia (Beutler and Cerami 1986;Beutler 1990). In mice and humans, TNF is synthesized by activated monocytes mainly as a 26 kd propeptide which is pro