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The presence of 17β-hydroxysteroid dehydrogenase activity in preimplantation rat and mouse blastocysts

✍ Scribed by Wu, Jung-Tsung ;Lin, Guey-Meei

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
296 KB
Volume
220
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

When Day 5 rat blastocysts and Day 4 and 5 mouse blastocysts were cultured in 53 μl of medium containing 1340 or 2680 pg [^3^H]estradiol (E~2~), large amounts of [^3^H]estrone (E~1~) were detected in the medium at daily intervals for up to 5 days. This indicates the presence of 17β‐hydroxysteroid dehydrogenase in the embryos. The activity was higher at a higher concentration of E~2~ and was also higher in mouse than in rat blastocysts. In the mouse, the activity was higher in Day 5 than Day 4 blastocysts during the first day in culture; then it decreased in Day 5 but increased in Day 4 blastocysts. The importance of E~2~ in embryonic development and implantation as suggested by others may be related to the activity of 17β‐hydroxysteroid dehydrogenase.

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