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The presence and possible role of phosphopantothenic acid in gramicidin S synthetase

โœ Scribed by C.C. Gilhuus-Moe; T. Kristensen; J.E. Bredesen; T.-L. Zimmer; S.G. Laland

Book ID
115901353
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
448 KB
Volume
7
Category
Article
ISSN
0014-5793

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Gramicidin S is a nonribosomally synthesized cyclic decapeptide antibiotic with twofold symmetry (Val-Orn-Leud-Phe-Pro) 2 ; a natural source is Bacillus brevis. Gramicidin S is active against Gram-positive and some Gram-negative bacteria. However, its haemolytic toxicity in humans limits its use as