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The preparation of α-substituted, β-hydroxy piperidines and pyrrolidines: The total synthesis of febrifugine

✍ Scribed by Laurence E. Burgess; Elizabeth K.M. Gross; Joe Jurka


Book ID
103403471
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
232 KB
Volume
37
Category
Article
ISSN
0040-4039

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Salicylamide condenses with y,6-or G&-unsaturated aldehydes to give cyclic amidals which readily undergo diastereoselective mercury(n)-mediated amidocyclization. The resulting products serve. as versatile intermediates for further elaboration as nitrogen heterocycles. Diastereoselcctive electrophili