Hydrolysis of the Phosphonamidate Bond i
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Artur Mucha; Jolanta Grembecka; Tomasz Cierpicki; PaweΕ Kafarski
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Article
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2003
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John Wiley and Sons
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English
β 153 KB
## Abstract Phosphonamidate pseudodipeptides, designed as transition state analogue inhibitors of leucine aminopeptidase, revealed unexpected instability in aqueous solutions of pH values varying from acidic up to highly basic. This reaction has been studied in some detail by means of NMR spectrosc