THE PREPARATION OF NICOTINIC ACID FROM PYRIDINE
โ Scribed by McElvain, S. M.; Goese, M. A.
- Book ID
- 115526003
- Publisher
- American Chemical Society
- Year
- 1941
- Tongue
- English
- Weight
- 209 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
## Abstract Methyl nicotinateโ5โ^2^H was prepared in dry tetrahydrofuran by palladiumโcatalyzed deuterolysis of methyl 5โbromonicotinate. Acid hydrolysis of the crude reaction mixture resulted in a 92% yield of deuteriumโlabeled nicotinic acid of which 80 mole% was nicotinicโ5โ^2^H acid and 12 mole
The preparation and bacteriostatic activity of several ortho substituted benzoic acids formed the subject of a recent NOTE (1) from this laboratory. Although closely related to 5-nitro-2-pyridyl phenyl sulfone, these acids showed no bacteriostatic activity toward Staphylococcus aureus comparable to