๐”– Bobbio Scriptorium
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THE PREPARATION OF NICOTINIC ACID FROM PYRIDINE

โœ Scribed by McElvain, S. M.; Goese, M. A.


Book ID
115526003
Publisher
American Chemical Society
Year
1941
Tongue
English
Weight
209 KB
Volume
63
Category
Article
ISSN
0002-7863

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๐Ÿ“œ SIMILAR VOLUMES


Preparation of nicotinic-5-2H acid from
โœ Brian R. Clark ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 257 KB

## Abstract Methyl nicotinateโ€5โ€^2^H was prepared in dry tetrahydrofuran by palladiumโ€catalyzed deuterolysis of methyl 5โ€bromonicotinate. Acid hydrolysis of the crude reaction mixture resulted in a 92% yield of deuteriumโ€labeled nicotinic acid of which 80 mole% was nicotinicโ€5โ€^2^H acid and 12 mole

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The preparation and bacteriostatic activity of several ortho substituted benzoic acids formed the subject of a recent NOTE (1) from this laboratory. Although closely related to 5-nitro-2-pyridyl phenyl sulfone, these acids showed no bacteriostatic activity toward Staphylococcus aureus comparable to