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The preparation of N-alkyl-2(1H)-pyridones by ther reaction of amines with a derivative of 3-(2-pyridyl)propane-1,2-diol

✍ Scribed by Michael H. Block

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 128 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)74744-7

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✦ Synopsis

The redwdou of the 2-pyridyl onhster derivative 7 with DIBAL gives excluively the semoduy alco&ol9 in excellent yield. MesyliMioo of 9 followed by reaction with amioes @es the unuwai &alkyL2(lk& pylidms 11 mdl2.

Recently a new preparation of N-alkyl-2(1&-pyridones (3) has been reported which involved a novel reaction of benzoic acid, phenol and thiophenol with 2-glycidoxy-pyridines (1) bearing electron withdrawing

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## Abstract For Abstract see ChemInform Abstract in Full Text.