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The Preparation of Morphine-N-methyl-C14

✍ Scribed by Rapoport, Henry; Lovell, Calvin H.; Tolbert, Bert M.


Book ID
111965033
Publisher
American Chemical Society
Year
1951
Tongue
English
Weight
151 KB
Volume
73
Category
Article
ISSN
0002-7863

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## Abstract Protected morphine‐6‐glucuronide was converted into morphine‐[__N__‐methyl‐^14^C]‐6‐glucuronide by a three‐step procedure. Methyl (3‐pivaloylmorphin‐6‐yl 2,3,4‐tri‐__O__‐isobutyryl‐__β__‐D‐glucopyranosid)uronate was N‐demethylated by treatment with 1‐chloroethyl chloroformate to afford