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The preparation of aromatic astatine compounds through aromatic mercury compounds part II: Astatination of pyrimidines and steroids

✍ Scribed by Gerard W. M. Visser; Eduard L. Diemer; Frans M. Kaspersen

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
424 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Several ^211^At‐astatopyrimidines (5‐At‐uracil, 5‐At‐cytosine and their nucleosides and nucleotides including DNA and RNA) have been synthesized in high radiochemical yields by reaction of ^211^At/I~2~ and the corresponding chloromercury compounds. Also some astato‐steroids (6‐At‐cholesterol and 2‐ and 4‐astatoestradiol) have been prepared by this method. The stability in vitro was determined under different conditions in comparison with the analogous iodo compounds.

📜 SIMILAR VOLUMES

The preparation of aromatic astatine com
The preparation of aromatic astatine compounds through aromatic mercury-compounds
✍ Gerard W. M. Visser; Eduard L. Diemer; Frans M. Kaspersen 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 374 KB

## Abstract Aromatic astatine compounds can be prepared under mild conditions in high yields by reaction of astatine with aromatic mercury compounds. Compared to direct electrophilic astatination this procedure is an easy and clean method for the introduction of astatine in aromatic compounds.