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The preparation of 5-bromofuroic acid

โœ Scribed by Roland M. Whittaker


Book ID
104585444
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
248 KB
Volume
52
Category
Article
ISSN
0165-0513

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๐Ÿ“œ SIMILAR VOLUMES


Preparation of nicotinic-5-2H acid from
โœ Brian R. Clark ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 257 KB

## Abstract Methyl nicotinateโ€5โ€^2^H was prepared in dry tetrahydrofuran by palladiumโ€catalyzed deuterolysis of methyl 5โ€bromonicotinate. Acid hydrolysis of the crude reaction mixture resulted in a 92% yield of deuteriumโ€labeled nicotinic acid of which 80 mole% was nicotinicโ€5โ€^2^H acid and 12 mole