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The preparation of 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides by the condensation/cyclization of trilithiated acetoacetanilides with lithiated methyl salicylates

✍ Scribed by Douglas R. Hurst; Kristen L. French; April J. Angel; Angela R. Williams; Mary E. Rampey; Tina S. Guion; Kam W. Chan; Camille M. Kassis; Shannon L. Studer Martinez; Charles F. Beam

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
252 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Several acetoacetanilides were trilithiated in excess lithium diisopropylamide, and the resulting polylithiated intermediates were regioselectively condensed with lithiated methyl salicylates followed by acid cyclization to substituted 4‐oxo‐N‐aryl‐4__H__‐1‐benzopyran‐2‐acetamides (benzopyranone‐2‐acetamides).

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