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The Pregnane X Receptor Locus Is Associated With Susceptibility to Inflammatory Bowel Disease

✍ Scribed by Megan M. Dring; Carol A. Goulding; Valerie I. Trimble; Denise Keegan; Anthony W. Ryan; Karen M. Brophy; Claire M. Smyth; P.W. Napoleon Keeling; Diarmuid O’Donoghue; Maria O’Sullivan; Colm O’Morain; Nasir Mahmud; Ann–Charlotte Wikström; Dermot Kelleher; Ross McManus

Book ID
118230467
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
132 KB
Volume
130
Category
Article
ISSN
0016-5085

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✍ Jürgen Glas; Julia Seiderer; Daniel Fischer; Barbara Tengler; Simone Pfennig; Ma 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB

## Background: The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 ge