The preferred conformation of the ester group in relation to saturated ring systems
β Scribed by A. McL. Mathieson
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- French
- Weight
- 317 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
We have previously (2) described an unusual type of conformational preference effect vhich vaa found to operate in ring A of some 3-substituted (-OH and -N3), A 5(10) -steroids. From the RMR spectra of these epimer pairs in the C-3 proton region, It was evident that the 3a-and
Pipecolic acid derivatives have proven to be effective Pi groups in a series of highly potent inhibitors of the enzyme HIV protease. One such inhibitor, Ro 31-8959, contains the saturated bicyclic ring system decahydroisoquinoline (DIQ) in the Pi position. The binding orientation of Ro 31-8959 is kn