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The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex

✍ Scribed by Jennifer L. Cyr; Graham D. Brown; Jennifer Stroop; Christopher D. Heinen


Book ID
112142310
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
488 KB
Volume
51
Category
Article
ISSN
0899-1987

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## Communicated by Riccardo Fodde Numerous unclassified variants (UVs) have been found in the mismatch repair genes MLH1 and MSH2 involved in hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Some of these variants may have an effect on pre-mRNA splicing, either by altering dege