The practical procedure for a preparation of 1-chloroalkyl p-tolyl sulfoxides in high optically active form: A very short synthesis of optically active disparlure

A novel method for the asymmetric synthe

A novel method for the asymmetric synthesis of 4,4-disubstituted 2-cyclopentenones from optically active 1-chlorovinyl p-tolyl sulfoxides and its application to the asymmetric total synthesis of (+)-α-cuparenone

✍ Tsuyoshi Satoh; Masaaki Yoshida; Yasuhiro Takahashi; Hiroyuki Ota 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 411 KB

Enantiomerically pure 1-chlorovinyl p-tolyl sulfoxides having two different substituents at the 2-position were synthesized from unsymmetrical ketones and (R)-(-)-chloromethyl p-tolyl sulfoxide in three steps. Treatment of the 1-chlorovinyl p-tolyl sulfoxides with cyanomethyllithium at -78°C to room