✦ LIBER ✦

The potentiation of the non-behavioural effects of amphetamine by carbon disulphide

✍ Scribed by Stefano Caroldi; Laszlo Magos; Jack Jarvis; Philip Forshaw; Roger T. Snowden

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 387 KB
Volume: 7
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550070111

No coin nor oath required. For personal study only.

✦ Synopsis

In agreement with the inhibition of dopamine-8-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus. The extension of exposure time also increased the toxicity of amphetamine. In conscious animals the stereotypic activity produced by 6.0 mg/kg and even that of 3.0 mg/kg amphetamine sulphate was suppressed by severe hyperthermia resulting in exhaustion, prostration and eventually death. A 16 h exposure to CS2 did not increase the lethal or hyperthermic effects of amphetamine in rats anaesthetized with 60 mg/kg sodium pentobarbitone. In fact the CS2 exposed rats became more hypothermic than non-exposed rats.

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