Clinical development plan: N-acetyl-l-cy
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NCI, DCPC Chemoprevention Branch and Agent Development Committee
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Article
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1994
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John Wiley and Sons
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English
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N-Acetyl-I-cysteine (NAC) is a thiol-containing nucleophile which can detoxify electrophiles and free radicals by direct [ 1 4 ] and enzymatic conjugation [5]. More importantly, the agent also serves as a precursor of intracellular cysteine and glutathione (GSH) [3,6], and enhances the activities of