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The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region

✍ Scribed by Deery, Alastair

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 75 KB
Volume: 187
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199904)187:5<600::aid-path297>3.0.co;2-8

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✦ Synopsis

We question the originality or the practically evidenced theoretical utility of the paper by Sturm et al. 1 Could the authors be requested to explain their lack of rigour in referencing the existing literature? The sensitivity of 'real' prospective biliary brush cytology for carcinoma is evidenced to be as high as single endoscopic brush or biopsy work from any other epithelial surface, 2 contrary to the authors' assertions. The specificity of brush cytology is near absolute, with two exceptions reported in the early English literature. 3,4 Lastly, a prospective clinical study of the use of one approach to K-ras gene mutation analysis in bile samples is already in print 5 and the sensitivity and specificity of this marker are not high.

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The potential diagnostic use of K-ras co

The potential diagnostic use of K-ras codon 12 andp53 alterations in brush cytology from the pancreatic head region

✍ Sturm, Patrick D. J.; Hruban, Ralph H.; Ramsoekh, Teun B.; Noorduyn, L. Arnold; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 1 views

It can be difficult to distinguish between malignant and benign disease of the region of the head of the pancreas using conventional methods. K-ras and p53 alterations occur frequently in malignancies in this region and are therefore candidate tumour markers. To define the utility of these alteratio